Which of the following statements is true regarding asthma medications?

The statement that controller medications are essential for managing persistent asthma is true. Controller medications, such as inhaled corticosteroids and long-acting beta-agonists, are specifically designed to address the underlying inflammation and bronchoconstriction associated with persistent asthma. They help to reduce the frequency and severity of asthma symptoms over time and are typically taken regularly, regardless of the presence of symptoms, to maintain asthma control.

In contrast, other options describe scenarios that do not accurately reflect the role of asthma medications in management. For instance, short-acting beta-agonists (SABAs) are intended for quick relief of acute symptoms rather than long-term management, and they cannot substitute for the ongoing control provided by controller medications. Additionally, controller medications are not meant for immediate relief; that role is specifically filled by rescue medications like SABAs. Thus, focusing on the proper use of controller medications is crucial for effective management of persistent asthma.