What is the recommended drug therapy for a 5-11 year old with persistent severe asthma?

The recommended drug therapy for a 5-11-year-old with persistent severe asthma typically involves combining a high-dose inhaled corticosteroid (ICS) with a long-acting beta-agonist (LABA) and, in most cases, oral corticosteroids to manage severe inflammation and to control symptoms effectively. This combination addresses both the underlying inflammation in the airways with the high-dose ICS and bronchodilation provided by the LABA, ensuring optimal asthma control.

Utilizing oral corticosteroids in cases of persistent severe asthma may be necessary for patients experiencing frequent exacerbations or those who do not adequately respond to high-dose ICS and LABA therapy alone. This approach is key to stabilizing the patient's condition, preventing acute asthma attacks, and improving quality of life.

In contrast, other treatment options may not provide sufficient control for severe asthma. Low-dose ICS and LABA, for instance, generally serve well for moderate persistent asthma but can be inadequate for severe cases. Medium-dose ICS, while an option for some patients, typically does not offer the intensive level of control needed for those with severe persistent asthma. High-dose ICS paired with a leukotriene receptor antagonist (LTRA) may be beneficial, but it typically does not match the dual action of adding a